mPEG(1k/2k/3k/4k/5k/10k/20k)
PLGA(500~500K)
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中文名称:聚乙二醇-b-聚乙丙交酯(x/y)
英文名称:mPEG-b-PLGA
两亲性嵌段共聚物 (AmBC) 由两种化学结构不同的均聚物嵌段组成。其中一个是亲水性的,另一个是疏水性的。这些大分子在水性介质中溶解时具有自组装的属性。PEG-PLGA 是一种最常用的可生物降解的两亲性嵌段共聚物,用于药物输送。PEG 是亲水性部分,PLGA 是疏水性部分。用于合成用于药物差异递送和控释的靶向纳米颗粒。
生物相容性好,免疫原性低,可降解性好。通过改变嵌段共聚物链段大小以适应特定的应用,可以很容易地调节性质
Amphiphilic block copolymer (AMBC) is composed of two homopolymer blocks with different chemical structures. One is hydrophilic and the other is hydrophobic. These macromolecules have the property of self-assembly when dissolved in aqueous medium. Peg-plga is one of the most commonly used biodegradable amphiphilic block copolymers for drug delivery. Peg is the hydrophilic part and PLGA is the hydrophobic part. It is used to synthesize targeted nanoparticles for drug differential delivery and controlled release.
Good biocompatibility, low immunogenicity and good degradability.
The properties can be easily adjusted by changing the segment size of block copolymer to adapt to specific applications.
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