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中文名称:1,4-二氧杂环-2,5-己二酮、乙交酯、羟基乙酸交酯
英文名称:1,4-Dioxane-2,5-dione、Glycolide、2,5-dioxo-1,4-dioxane
乙交酯是α羟基酸的环状二聚体,可用于制备脂肪族聚酯。它通过甘醇酸的二聚化而合成。它可制备低毒的人造生物可降解聚合物,适于医疗应用。它主要用于通过开环聚合反应形成高度结晶的聚乙交酯。
乙交酯作为聚合单体,既可以均聚得到聚乙交酯,又可以和其他环状单体开环共聚,得到无规共聚物或嵌段共聚物,它们作为可生物降解的高分子材料中的一类,在医用高分子材料的研究和开发中占有重要地位,在手术缝合线、人造皮肤及血管、骨骼固定及修复、药物控制释放、组织工程等许多领域得到了应用。
Glycolide is α The cyclic dimer of hydroxyl acid can be used to prepare aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It can prepare artificial biodegradable polymers with low toxicity and is suitable for medical applications. It is mainly used to form highly crystalline polyglycolide through ring opening polymerization.
As a polymeric monomer, glycolide can be homopolymerized to polyglycolide, and can also be ring opened copolymerized with other cyclic monomers to obtain random copolymers or block copolymers. As a kind of biodegradable polymer materials, they play an important role in the research and development of medical polymer materials, and play an important role in surgical suture, artificial skin and blood vessels, bone fixation and repair, drug controlled release Tissue engineering and many other fields have been applied.
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